AustralieFrV1, Main, Exploration, bibRecord, 003665

Oncostatin M acting via OSMR, augments the actions of IL-1 and TNF in synovial fibroblasts.

Identifieur interne : 003665 ( Main/Exploration ); précédent : 003664; suivant : 003666

Oncostatin M acting via OSMR, augments the actions of IL-1 and TNF in synovial fibroblasts.

Auteurs : Benoit Le Goff [France] ; Sofie Singbrant [Australie] ; Brett A. Tonkin [Australie] ; T John Martin [Australie] ; Evange Romas [Australie] ; Natalie A. Sims [Australie] ; Nicole C. Walsh [Australie]

Source :

Cytokine [ 1096-0023 ] ; 2014.

RBID : pubmed:24767864

Descripteurs français

English descriptors

KwdEn :
- Animals, Arthritis, Rheumatoid (genetics), Arthritis, Rheumatoid (pathology), Fibroblasts (metabolism), Gene Expression Regulation, Humans, Interleukin-1beta (genetics), Interleukin-1beta (metabolism), Mice, Inbred C57BL, Oncostatin M (metabolism), Osteoprotegerin (genetics), Osteoprotegerin (metabolism), RANK Ligand (genetics), RANK Ligand (metabolism), RNA, Messenger (genetics), RNA, Messenger (metabolism), Receptors, Interleukin-1 (metabolism), Receptors, Oncostatin M (deficiency), Receptors, Oncostatin M (metabolism), Synovial Membrane (pathology), Tumor Necrosis Factor-alpha (metabolism).
MESH :
- chemical , deficiency : Receptors, Oncostatin M.
- chemical , genetics : Interleukin-1beta, Osteoprotegerin, RANK Ligand, RNA, Messenger.
- genetics : Arthritis, Rheumatoid.
- metabolism : Fibroblasts, Interleukin-1beta, Oncostatin M, Osteoprotegerin, RANK Ligand, RNA, Messenger, Receptors, Interleukin-1, Receptors, Oncostatin M, Tumor Necrosis Factor-alpha.
- pathology : Arthritis, Rheumatoid, Synovial Membrane.
- Animals, Gene Expression Regulation, Humans, Mice, Inbred C57BL.

Abstract

To identify how the gp130-signaling cytokine oncostatin M (OSM), acting alone or in concert with IL-1β or TNFα, affects synovial fibroblast expression of genes relevant to inflammation and bone erosion in inflammatory arthritis.

DOI: 10.1016/j.cyto.2014.04.001
PubMed: 24767864

Affiliations:

Le document en format XML

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<settlement type="city">Melbourne</settlement>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term>
<term>Arthritis, Rheumatoid (genetics)</term>
<term>Arthritis, Rheumatoid (pathology)</term>
<term>Fibroblasts (metabolism)</term>
<term>Gene Expression Regulation</term>
<term>Humans</term>
<term>Interleukin-1beta (genetics)</term>
<term>Interleukin-1beta (metabolism)</term>
<term>Mice, Inbred C57BL</term>
<term>Oncostatin M (metabolism)</term>
<term>Osteoprotegerin (genetics)</term>
<term>Osteoprotegerin (metabolism)</term>
<term>RANK Ligand (genetics)</term>
<term>RANK Ligand (metabolism)</term>
<term>RNA, Messenger (genetics)</term>
<term>RNA, Messenger (metabolism)</term>
<term>Receptors, Interleukin-1 (metabolism)</term>
<term>Receptors, Oncostatin M (deficiency)</term>
<term>Receptors, Oncostatin M (metabolism)</term>
<term>Synovial Membrane (pathology)</term>
<term>Tumor Necrosis Factor-alpha (metabolism)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>ARN messager (génétique)</term>
<term>ARN messager (métabolisme)</term>
<term>Animaux</term>
<term>Facteur de nécrose tumorale alpha (métabolisme)</term>
<term>Fibroblastes (métabolisme)</term>
<term>Humains</term>
<term>Interleukine-1 bêta (génétique)</term>
<term>Interleukine-1 bêta (métabolisme)</term>
<term>Ligand de RANK (génétique)</term>
<term>Ligand de RANK (métabolisme)</term>
<term>Membrane synoviale (anatomopathologie)</term>
<term>Oncostatine M (métabolisme)</term>
<term>Ostéoprotégérine (génétique)</term>
<term>Ostéoprotégérine (métabolisme)</term>
<term>Polyarthrite rhumatoïde (anatomopathologie)</term>
<term>Polyarthrite rhumatoïde (génétique)</term>
<term>Récepteurs à l'interleukine-1 (métabolisme)</term>
<term>Récepteurs à l'oncostatine M (déficit)</term>
<term>Récepteurs à l'oncostatine M (métabolisme)</term>
<term>Régulation de l'expression des gènes</term>
<term>Souris de lignée C57BL</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="deficiency" xml:lang="en"><term>Receptors, Oncostatin M</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Interleukin-1beta</term>
<term>Osteoprotegerin</term>
<term>RANK Ligand</term>
<term>RNA, Messenger</term>
</keywords>
<keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Membrane synoviale</term>
<term>Polyarthrite rhumatoïde</term>
</keywords>
<keywords scheme="MESH" qualifier="déficit" xml:lang="fr"><term>Récepteurs à l'oncostatine M</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Arthritis, Rheumatoid</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>ARN messager</term>
<term>Interleukine-1 bêta</term>
<term>Ligand de RANK</term>
<term>Ostéoprotégérine</term>
<term>Polyarthrite rhumatoïde</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Fibroblasts</term>
<term>Interleukin-1beta</term>
<term>Oncostatin M</term>
<term>Osteoprotegerin</term>
<term>RANK Ligand</term>
<term>RNA, Messenger</term>
<term>Receptors, Interleukin-1</term>
<term>Receptors, Oncostatin M</term>
<term>Tumor Necrosis Factor-alpha</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>ARN messager</term>
<term>Facteur de nécrose tumorale alpha</term>
<term>Fibroblastes</term>
<term>Interleukine-1 bêta</term>
<term>Ligand de RANK</term>
<term>Oncostatine M</term>
<term>Ostéoprotégérine</term>
<term>Récepteurs à l'interleukine-1</term>
<term>Récepteurs à l'oncostatine M</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Arthritis, Rheumatoid</term>
<term>Synovial Membrane</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Gene Expression Regulation</term>
<term>Humans</term>
<term>Mice, Inbred C57BL</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Animaux</term>
<term>Humains</term>
<term>Régulation de l'expression des gènes</term>
<term>Souris de lignée C57BL</term>
</keywords>
</textClass>
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<front><div type="abstract" xml:lang="en">To identify how the gp130-signaling cytokine oncostatin M (OSM), acting alone or in concert with IL-1β or TNFα, affects synovial fibroblast expression of genes relevant to inflammation and bone erosion in inflammatory arthritis.</div>
</front>
</TEI>
<affiliations><list><country><li>Australie</li>
<li>France</li>
</country>
<region><li>Pays de la Loire</li>
<li>Victoria (État)</li>
</region>
<settlement><li>Melbourne</li>
<li>Nantes</li>
</settlement>
<orgName><li>Université de Melbourne</li>
</orgName>
</list>
<tree><country name="France"><region name="Pays de la Loire"><name sortKey="Le Goff, Benoit" sort="Le Goff, Benoit" uniqKey="Le Goff B" first="Benoit" last="Le Goff">Benoit Le Goff</name>
</region>
</country>
<country name="Australie"><region name="Victoria (État)"><name sortKey="Singbrant, Sofie" sort="Singbrant, Sofie" uniqKey="Singbrant S" first="Sofie" last="Singbrant">Sofie Singbrant</name>
</region>
<name sortKey="Martin, T John" sort="Martin, T John" uniqKey="Martin T" first="T John" last="Martin">T John Martin</name>
<name sortKey="Romas, Evange" sort="Romas, Evange" uniqKey="Romas E" first="Evange" last="Romas">Evange Romas</name>
<name sortKey="Sims, Natalie A" sort="Sims, Natalie A" uniqKey="Sims N" first="Natalie A" last="Sims">Natalie A. Sims</name>
<name sortKey="Tonkin, Brett A" sort="Tonkin, Brett A" uniqKey="Tonkin B" first="Brett A" last="Tonkin">Brett A. Tonkin</name>
<name sortKey="Walsh, Nicole C" sort="Walsh, Nicole C" uniqKey="Walsh N" first="Nicole C" last="Walsh">Nicole C. Walsh</name>
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Serveur d'exploration sur les relations entre la France et l'Australie

Oncostatin M acting via OSMR, augments the actions of IL-1 and TNF in synovial fibroblasts.

Oncostatin M acting via OSMR, augments the actions of IL-1 and TNF in synovial fibroblasts.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	Serveur d'exploration sur les relations entre la France et l'Australie
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